Cortisol Awakening Response (CAR)

Shortly after awakening, the cortisol level in the saliva increases by approximately 70%. This increase is altered under stress. This phenomenon was first observed by the Trier workgroup in 1997 and is today one of the most frequently used methods for ambulatory assessment of endocrine effects of stress, burnout, depression and anxiety. The collection of saliva is carried out by the patient himself in his natural environment, thus having high ecological validity.